Low threshold T‐type calcium current in rat embryonic chromaffin cells
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چکیده
منابع مشابه
Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low-threshold current.
1. Calcium currents were recorded with whole-cell voltage-clamp procedures in relay neurones of the rat thalamus which had been acutely isolated by an enzymatic dissociation procedure. 2. Low-threshold and high-threshold Ca2+ currents were elicited by depolarizing voltage steps from holding potentials more negative than -60 mV. A transient current, analogous to the T-current in sensory neurones...
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Interneurons from the CA1 lacunosum-moleculare (L-M) region were isolated by trypsin-hyaluronidase treatment and mechanical trituration of the L-M. Interneurons isolated in this manner were multipolar with several dendritic processes and could be distinguished from CA1 pyramidal neurons. The properties of a low-threshold transient (LTT) Ca2+ current were investigated using whole-cell voltage-cl...
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Valproic acid (VPA) is an antiepileptic drug used in the treatment of a wide variety of human seizures including generalized absence (GA) (petit mal) seizures. The mechanism of action of VPA in controlling GA seizures is not known. We tested the effects of VPA on the Ca2+ current components of acutely dissociated rat nodose ganglion neurons. VPA reduced the low-threshold (T) Ca2+ current at cli...
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A silicon model of the thalamic low threshold calcium current is presented. The channel current (IT) is the product of an activation and inactivation current, normalized by their sum. The individual currents are modeled by a simple current-mirror integrator circuit. A modified differential pair controls the threshold of activation while a leak transistor added to the inactivation mirror control...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2001
ISSN: 0022-3751,1469-7793
DOI: 10.1111/j.1469-7793.2001.0035k.x